A new role for cohesin in regulating alternative splicing has been identified, providing insights into splicing mutations in human disease. Cohesin is known to play a key part in transcription, and ...

An international research team has uncovered a new mechanism crucial to the production of cellular proteins. When this mechanism is disrupted, the blueprints used by the cell to produce proteins are ...

Relevance and specificity of the French CIAN LUNG cohort for clinical research analyses in lung cancer using real-world data. The efficacy of daprodustat compared to standard recombinant human ...

Infographic: How “Silent” Mutations Can Disrupt Protein-Making Although scientists often assume that synonymous mutations don’t cause any biological effects because they don’t alter the amino acid ...

Researchers at Monash University in Melbourne, Australia, have uncovered the hidden code governing how genetic mutations affect RNA splicing and result in disease. The researchers were able to ...

Researchers have identified 813 possible cancer driver genes, significantly expanding the list of potential therapeutic targets for treating the disease. The genes help cancer cells grow through a non ...

Five-year outcomes with first-line (1L) nivolumab + ipilimumab + chemotherapy (N + I + C) vs C in patients (pts) with metastatic NSCLC (mNSCLC) in CheckMate 9LA. Co-occurring RNA splicing alterations ...

Researchers in the Landau lab, led by Dr. Dan Landau, hematology and medical oncology, recently developed a new technique to investigate how mutations in RNA splicing can lead to clonal hematopoiesis ...

Please provide your email address to receive an email when new articles are posted on . Few patients with cystic fibrosis have a copy of the 3849+10kb C-to-T splicing mutation. Research is planned to ...

It may be time to rethink certain genetic mutations associated with two devastating neurodegenerative disorders—amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)—according to a new ...